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导师简介

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刘东

日期:2020-04-15   点击数:512  

姓名:刘东

职称:教授

联系方式:0513-85012809

E-mail: liudongtom@gmail.com

科研团队网页:/ldsys/main.htm

学历及学术经历:

教授,博士生导师,江苏省杰出青年基金获得者。于2011年获德国马克斯-德尔布吕克分子医学中心(Max-Delbrück Center for Molecular Medicine)/柏林自由大学(Freie Universität Berlin),自然科学博士学位。江苏省第五期“333高层次人才培养工程”培养对象、江苏省“六大人才高峰”高层次人才培养对象、获江苏省“双创计划”资助。中国研究型医院学会运动医学专业委员会委员;美国心脏协会American Heart Association会员;中国解剖学会青年工作委员会委员;中国解剖学会再生医学专业委员会委员;中国生物物理学会听觉分会委员,青年委员会常务委员;中国研究型医院学会运动医学专业委员会委员;江苏省发育与细胞学会理事;江苏省神经科学会理事;江苏省发育生物学会听觉科学专业委员会副主任委员;江苏省神经科学会青年委员会委员。相关研究成果在学术界有广泛的影响,曾被国内外几百家媒体报道和评论,包括新华社、科技日报和著名科技期刊Nature等。主讲本科生《医学遗传学》和研究生《高级分子生物学》等课程。

 

主持课题:

2019-2024:国家重点研发计划“发育编程及其代谢调节”重点专项“斑马鱼发育与代谢突变体库的系统创制”重点专项子项目负责人

2019-2022: 国家自然科学基金-面上项目:血管新生的遗传调控(H0220

2016-2019: 国家自然科学基金-面上项目:血管新生的遗传调控(H0220

2013-2015: 国家自然科学基金-青年项目:血管新生的遗传调控

2018-2021: 江苏省自然科学基金-杰出青年基金项目(H0220

2012-2015: 江苏省自然科学基金-青年基金项目

2017-2020: 江苏省高校自然科学研究项目-重大项目:血管新生

2020-2021: 省第五期“333 工程”培养资金资助项目(BRA2019278)

2016-2019: 江苏省“六大人才高峰”高层次人才培养对象:血管新生

2014-2016: 江苏省“双创计划”博士计划,境外世界名校创新类计划

2012-2014: 江苏省高校自然科学研究项目-面上项目

 

主要研究领域:

1、生理和病理条件下血管新生的遗传调控

2、神经发育以及相关疾病的发病机制

3、基于血管内皮细胞、毛细胞和运动神经元行为的化合物筛选

 

代表性论文(2016年以来):

1.      Zhang Z, Hou H, Yu S, Zhou C, Zhang X, Li N, Zhang S, Song K, Lu Y, Liu D, Lu H, Xu H. Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia. 2020;68(1):111-27. Epub 2019/08/25. doi: 10.1002/glia.23707. PubMed PMID: 31444939.

2.      Wang B, Xu M, Li M, Wu F, Hu S, Chen X, Zhao L, Huang Z, Lan F, Liu D, Wang Y. miR-25 Promotes Cardiomyocyte Proliferation by Targeting FBXW7. Mol Ther Nucleic Acids. 2020;19:1299-308. Epub 2020/03/13. doi: 10.1016/j.omtn.2020.01.013. PubMed PMID: 32160702; PMCID: PMC7044498.(通讯作者)

3.      Hu Z, Wang S, Zhang C, Gao N, Li M, Wang D, Wang D, Liu D, Liu H, Ong SG, Wang H, Wang Y. A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope. PLoS Biol. 2020;18(3):e3000686. Epub 2020/04/01. doi: 10.1371/journal.pbio.3000686. PubMed PMID: 32226015.

4.      Gong J, Hu S, Huang Z, Hu Y, Wang X, Zhao J, Qian P, Wang C, Sheng J, Lu X, Wei G, Liu D. The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish. Frontiers in molecular neuroscience. 2020;13:34. Epub 2020/04/16. doi: 10.3389/fnmol.2020.00034. PubMed PMID: 32292330; PMCID: PMC7135881.(通讯作者)

5.      Zhang K, Zhang H, Zhou H, Crookes D, Li L, Shao Y, Liu D. Zebrafish Embryo Vessel Segmentation Using a Novel Dual ResUNet Model. Comput Intell Neurosci. 2019;2019:8214975. Epub 2019/03/14. doi: 10.1155/2019/8214975. PubMed PMID: 30863436; PMCID: PMC6378085. (通讯作者)

6.      Zhang H, Gao Y, Qian P, Dong Z, Hao W, Liu D, Duan X. Expression analysis of Rab11 during zebrafish embryonic development. BMC Dev Biol. 2019;19(1):25. Epub 2019/12/31. doi: 10.1186/s12861-019-0207-7. PubMed PMID: 31884948; PMCID: PMC6936149.

7.      Yu B, Yao C, Wang Y, Mao S, Wang Y, Wu R, Feng W, Chen Y, Yang J, Xue C, Liu D, Ding F, Gu X. The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats. Frontiers in molecular neuroscience. 2019;12:287. Epub 2019/12/12. doi: 10.3389/fnmol.2019.00287. PubMed PMID: 31824262; PMCID: PMC6883948.

8.      Wang YM, Zheng YF, Yang SY, Yang ZM, Zhang LN, He YQ, Gong XH, Liu D, Finnell RH, Qiu ZL, Du YS, Wang HY. MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ. 2019;26(10):1863-79. Epub 2018/12/19. doi: 10.1038/s41418-018-0257-6. PubMed PMID: 30560934; PMCID: PMC6748079.

9.      Wang D, Zhang C, Wang B, Li B, Wang Q, Liu D, Wang H, Zhou Y, Shi L, Lan F, Wang Y. Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nat Commun. 2019;10(1):4284. Epub 2019/09/21. doi: 10.1038/s41467-019-12281-8. PubMed PMID: 31537810; PMCID: PMC6753114.

10.    Shi Y, Wang X, Shi Y, Zhang J, Zhao S, Yin Z, Xu G, Duan X, Guo Z, Liang X, Liu D. Two Compounds Isolated From Ganglioside GM1 Promote Angiogenesis in Zebrafish. J Cardiovasc Pharmacol. 2019;74(1):71-9. Epub 2019/07/06. doi: 10.1097/FJC.0000000000000683. PubMed PMID: 31274845. (通讯作者)

11.    Shi Y, Duan X, Xu G, Wang X, Wei G, Dong S, Xie G, Liu D. A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis. 2019;22(2):211-21. Epub 2019/01/19. doi: 10.1007/s10456-019-09663-3. PubMed PMID: 30656567. (通讯作者)

12.    Qin Y, Wang S, Duan X, Liu D. Expression analysis of the aquaporins during zebrafish embryonic development. Gene expression patterns : GEP. 2019;32:38-43. Epub 2019/04/06. doi: 10.1016/j.gep.2019.04.001. PubMed PMID: 30951885. (通讯作者)

13.    Li L, Zhu M, Wu W, Qin B, Gu J, Tu Y, Chen J, Liu D, Shi Y, Liu X, Sang A, Ding D. Brivanib, a multitargeted small-molecule tyrosine kinase inhibitor, suppresses laser-induced CNV in a mouse model of neovascular AMD. J Cell Physiol. 2019. Epub 2019/07/05. doi: 10.1002/jcp.29041. PubMed PMID: 31270802.

14.    Dong Z, Wu S, Zhu C, Wang X, Li Y, Chen X, Liu D, Qiang L, Baas PW, Liu M. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic. 2019;20(1):71-81. Epub 2018/11/10. doi: 10.1111/tra.12621. PubMed PMID: 30411440; PMCID: PMC6317882.

15.    Yan W, Liu W, Qi J, Fang Q, Fan Z, Sun G, Han Y, Zhang D, Xu L, Wang M, Li J, Chen F, Liu D, Chai R, Wang H. A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro. Molecular neurobiology. 2018;55(3):2070-84. Epub 2017/03/12. doi: 10.1007/s12035-017-0471-0. PubMed PMID: 28283883. (通讯作者)

16.    Shan Y, You B, Shi S, Shi W, Zhang Z, Zhang Q, Gu M, Chen J, Bao L, Liu D, You Y. Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases. Cell Death Dis. 2018;9(3):382. Epub 2018/03/09. doi: 10.1038/s41419-018-0425-0. PubMed PMID: 29515112; PMCID: PMC5841433. (通讯作者)

17.    Li B, Yu L, Liu D, Yang X, Zheng Y, Gui Y, Wang H. MIB1 Mutations Reduce Notch Signaling Activation and Contribute to Congenital Heart Disease. Clin Sci (Lond). 2018. Epub 2018/10/17. doi: 10.1042/CS20180732. PubMed PMID: 30322850.

18.    Gong J, Chai L, Xu G, Ni Y, Liu D. The expression of natriuretic peptide receptors in developing zebrafish embryos. Gene expression patterns : GEP. 2018;29:65-71. doi: 10.1016/j.gep.2018.07.001. PubMed PMID: 30018004. (通讯作者)

19.    Bao L, You B, Shi S, Shan Y, Zhang Q, Yue H, Zhang J, Zhang W, Shi Y, Liu Y, Wang X, Liu D, You Y. Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10. Oncogene. 2018;37(21):2873-89. doi: 10.1038/s41388-018-0183-6. PubMed PMID: 29520105; PMCID: PMC5966363. (通讯作者)

20.    Zhang J, Qi J, Wu S, Peng L, Shi Y, Yang J, Yin Z, Gao Y, Wang C, Gong J, Zhang H, Zhang J, Liu D. Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in physiology. 2017;8:214. doi: 10.3389/fphys.2017.00214. PubMed PMID: 28443032; PMCID: 5387095. (通讯作者)

21.    Xie Y, Wang D, Lan F, Wei G, Ni T, Chai R, Liu D, Hu S, Li M, Li D, Wang H, Wang Y. An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Scientific reports. 2017;7(1):2320. doi: 10.1038/s41598-017-02456-y. PubMed PMID: 28539611; PMCID: 5443789.

22.    Wang F, Liu D, Zhang RR, Yu LW, Zhao JY, Yang XY, Jiang SS, Ma D, Qiao B, Zhang F, Jin L, Gui YH, Wang HY. A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population. Cell discovery. 2017;3:17026. doi: 10.1038/celldisc.2017.26. PubMed PMID: 28761722; PMCID: 5527299. (并列一作)

23.    Mu Z, Zhang S, He C, Hou H, Liu D, Hu N, Xu H. Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neuroscience bulletin. 2017;33(1):53-61. doi: 10.1007/s12264-016-0073-2. PubMed PMID: 27743342.

24.    Lv F, Zhu C, Yan X, Wang X, Liu D. Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells. Fish physiology and biochemistry. 2017;43(1):287-94. doi: 10.1007/s10695-016-0286-3. PubMed PMID: 27632017. (通讯作者)

25.    Jin D, Zhu D, Fang Y, Chen Y, Yu G, Pan W, Liu D, Li F, Zhong TP. Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. Journal of genetics and genomics = Yi chuan xue bao. 2017;44(10):483-92. doi: 10.1016/j.jgg.2017.07.005. PubMed PMID: 29037991.

26.    He Z, Guo L, Shu Y, Fang Q, Zhou H, Liu Y, Liu D, Lu L, Zhang X, Ding X, Liu D, Tang M, Kong W, Sha S, Li H, Gao X, Chai R. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy. 2017:1-21. doi: 10.1080/15548627.2017.1359449. PubMed PMID: 28968134.

27.    He Y, Lu X, Qian F, Liu D, Chai R, Li H. Insm1a Is Required for Zebrafish Posterior Lateral Line Development. Frontiers in molecular neuroscience. 2017;10:241. doi: 10.3389/fnmol.2017.00241. PubMed PMID: 28824372; PMCID: 5539400.

28.    Gong J, Wang X, Zhu C, Dong X, Zhang Q, Wang X, Duan X, Qian F, Shi Y, Gao Y, Zhao Q, Chai R, Liu D. Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience. 2017;10:274. doi: 10.3389/fnmol.2017.00274. PubMed PMID: 28894416; PMCID: 5581358. (通讯作者)

29.    Zhang S, Mu Z, He C, Zhou M, Liu D, Zhao XF, Goldman D, Xu H. Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Muller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Investigative ophthalmology & visual science. 2016;57(4):1991-2000. doi: 10.1167/iovs.15-18669. PubMed PMID: 27096757; PMCID: 4849886.

30.    Wang X, Yuan W, Wang X, Qi J, Qin Y, Shi Y, Zhang J, Gong J, Dong Z, Liu X, Sun C, Chai R, Le Noble F, Liu D. The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget. 2016;7(47):77749-63. doi: 10.18632/oncotarget.12793. PubMed PMID: 27780917; PMCID: 5363618. (通讯作者)

31.    Wang X, Ling CC, Li L, Qin Y, Qi J, Liu X, You B, Shi Y, Zhang J, Jiang Q, Xu H, Sun C, You Y, Chai R, Liu D. MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular research. 2016;110(1):140-50. doi: 10.1093/cvr/cvw023. PubMed PMID: 26825552. (通讯作者)

32.    Shi YW, Yuan W, Wang X, Gong J, Zhu SX, Chai LL, Qi JL, Qin YY, Gao Y, Zhou YL, Fan XL, Ji CY, Wu JY, Wang ZW, Liu D. Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish. Scientific reports. 2016;6:30189. doi: 10.1038/srep30189. PubMed PMID: 27452835; PMCID: 4958954. (通讯作者)

33.   Qi J, Dong Z, Shi Y, Wang X, Qin Y, Wang Y, Liu D. NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell research. 2016;26(12):1349-52. doi: 10.1038/cr.2016.134. PubMed PMID: 27834346; PMCID: 5143420. (通讯作者)

34.    He Z, Zhang S, Song Q, Li W, Liu D, Li H, Tang M, Chai R. The structural development of primary cultured hippocampal neurons on a graphene substrate. Colloids and surfaces B, Biointerfaces. 2016;146:442-51. doi: 10.1016/j.colsurfb.2016.06.045. PubMed PMID: 27395037.